Whole-genome methylation sequencing reveals distinct impact of differential methylations on gene transcription in prostate cancer.

ABSTRACT: DNA methylation is one of the most important epigenetic mechanisms in regulating gene expression. Genome hypermethylation has been proposed as a critical mechanism in human malignancies. However, whole-genome quantification of DNA methylation of human malignancies has rarely been investigated, and the significance of the genome distribution of CpG methylation is unclear. We performed whole-genome methylation sequencing to investigate the methylation profiles of 13 prostate samples: 5 prostate cancers, 4 matched benign prostate tissues adjacent to tumor, and 4 age-matched organ-donor prostate tissues. Alterations of methylation patterns occurred in prostate cancer and in benign prostate tissues adjacent to tumor, in comparison with age-matched organ-donor prostates. More than 95% alteration

SUBMITTER: Yu YP 

PROVIDER: S-EPMC5745540 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature