⁶⁸Ga-PSMA 11 ligand PET imaging in patients with biochemical recurrence after radical prostatectomy - diagnostic performance and impact on therapeutic decision-making.

ABSTRACT:

Objective

To evaluate the diagnostic performance of [⁶⁸Ga]Ga-PSMA^HBED-CC conjugate 11 positron emission tomography (PSMA-PET) in the early detection of metastases in patients with biochemical recurrence (BCR) after radical prostatectomy (RP) for clinically non-metastatic prostate cancer, to compare it to CT/MRI alone and to assess its impact on further therapeutic decisions.

Material and methods

We retrospectively assessed 117 consecutive hormone-naïve BCR patients who had ⁶⁸Ga-PSMA 11 PET/CT (n = 46) or PET/MRI (n = 71) between May 2014 and January 2017. BCR was defined as two PSA rises above 0.2 ng/ml. Two dedicated uro-oncological imaging experts (radiology/nuclear medicine) reviewed separately all images. All results were presented in a b

SUBMITTER: Grubmuller B 

PROVIDER: S-EPMC5745568 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature