Chromosomal instability induced by increased BIRC5/Survivin levels affects tumorigenicity of glioma cells.

ABSTRACT:

Background

Survivin, belonging to the inhibitor of apoptosis (IAP) gene family, is abundantly expressed in tumors. It has been hypothesized that Survivin facilitates carcinogenesis by inhibition of apoptosis resulting in improved survival of tumorigenic progeny. Additionally, Survivin plays an essential role during mitosis. Together with its molecular partners Aurora B, Borealin and inner centromere protein it secures bipolar chromosome segregation. However, whether increased Survivin levels contribute to progression of tumors by inducing chromosomal instability remains unclear.

Methods

We overexpressed Survivin in U251-MG, SVGp12, U87-MG, HCT116 and p53-deficient U87-MG^shp53 and HCT116^p53-/- cells. The resulting phenotype was investigated by FACS-assis

SUBMITTER: Conde M 

PROVIDER: S-EPMC5745881 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature