Microbiota dysbiosis in inflammatory bowel diseases: in silico investigation of the oxygen hypothesis.

ABSTRACT:

Background

Inflammatory bowel diseases (IBD), which include ulcerative colitis and Crohn's disease, cause chronic inflammation of the digestive tract in approximately 1.6 million Americans. A signature of IBD is dysbiosis of the gut microbiota marked by a significant reduction of obligate anaerobes and a sharp increase in facultative anaerobes. Numerous experimental studies have shown that IBD is strongly correlated with a decrease of Faecalibacterium prausnitzii and an increase of Escherichia coli. One hypothesis is that chronic inflammation induces increased oxygen levels in the gut, which in turn causes an imbalance between obligate and facultative anaerobes.

Results

To computationally investigate the oxygen hypothesis, we developed a multispecies biofilm model based on g

SUBMITTER: Henson MA 

PROVIDER: S-EPMC5745886 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature