Resistant and susceptible chicken lines show distinctive responses to Newcastle disease virus infection in the lung transcriptome.

ABSTRACT:

Background

Newcastle disease virus (NDV) is a threat to poultry production worldwide. A better understanding of mechanisms of resistance and susceptibility to this virus will improve measures for NDV prevention and control. Males and females from resistant Fayoumi and susceptible Leghorn lines were either challenged with a lentogenic strain of the virus or given a mock infection at 3 weeks of age. The lung transcriptomes generated by RNA-seq were studied using contrasts across the challenged and nonchallenged birds, the two lines, and three time points post-infection, and by using Weighted Gene Co-expression Network Analysis (WGNCA).

Results

Genetic line and sex had a large impact on the lung transcriptome. When contrasting the challenged and nonchallenged birds, few differe

SUBMITTER: Deist MS 

PROVIDER: S-EPMC5745900 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature