Mycoplasma genitalium: whole genome sequence analysis, recombination and population structure.

ABSTRACT:

Background

Although Mycoplasma genitalium is a common sexually transmitted pathogen causing clinically distinct diseases both in male and females, few genomes have been sequenced up to now, due mainly to its fastidious nature and slow growth. Hence, we lack a robust phylogenetic framework to provide insights into the population structure of the species. Currently our understanding of the nature and diversity of M. genitalium relies on molecular tests targeting specific genes or regions of the genome and knowledge is limited by a general under-testing internationally. This is set against a background of drug resistance whereby M. genitalium has developed resistance to mainly all therapeutic antimicrobials.

Results

We sequenced 28 genomes of Mycoplasma genitalium from temporal

SUBMITTER: Fookes MC 

PROVIDER: S-EPMC5745988 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature