Study design and baseline findings from the progression of ocular findings (PROOF) natural history study of dry eye.

ABSTRACT:

Background

The aim of this research is to initiate a 5-year natural history study of dry eye disease (DED) using objectively assessed and patient-reported outcomes, to explore the hypothesis that DED is a progressive condition that has substantive and measurable impacts not only on the ocular surface, but on quality of life and visual functioning. Our objective for this report is to examine the baseline data.

Methods

A multicenter, prospective, controlled, observational study of Level 2 (mild-to-moderate) DED patients based on International Task Force Delphi Panel severity grading, and controls, documented baseline measures (including tear film biomarkers and quality of life). Tear cytokine concentrations were also measured in the tear film. Patients were using artificial te

SUBMITTER: McDonnell PJ 

PROVIDER: S-EPMC5746001 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature