Does azithromycin given to women in labour decrease ocular bacterial infection in neonates? A double-blind, randomized trial.

ABSTRACT:

Background

Vertical transmission can result in neonatal infection and disease. Reducing the transmission of bacterial pathogens from mother to infant may be an effective means of preventing neonatal infection, including bacterial conjunctivitis.

Methods

In a double-blind, randomized trial, we assessed the effect of administering a single dose of oral azithromycin to women in labour on bacterial colonization of the neonate. A reduction in purulent neonatal conjunctivitis was a secondary objective of the trial. Ocular samples were collected from the lower fornix of infants presenting with clinical signs of purulent conjunctivitis during the first eight weeks of life. Incidence of purulent conjunctivitis was compared between trial arms. Bacterial infection was assessed using PC

SUBMITTER: Burr SE 

PROVIDER: S-EPMC5746019 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature