Chemical exchange saturation transfer (CEST) MR technique for in-vivo liver imaging at 3.0 tesla.

ABSTRACT: PURPOSE:To evaluate Chemical Exchange Saturation Transfer (CEST) MRI for liver imaging at 3.0-T. MATERIALS AND METHODS:Images were acquired at offsets (n = 41, increment = 0.25 ppm) from -5 to 5 ppm using a TSE sequence with a continuous rectangular saturation pulse. Amide proton transfer-weighted (APTw) and GlycoCEST signals were quantified as the asymmetric magnetization transfer ratio (MTRasym) at 3.5 ppm and the total MTRasym integrated from 0.5 to 1.5 ppm, respectively, from the corrected Z-spectrum. Reproducibility was assessed for rats and humans. Eight rats were devoid of chow for 24 hours and scanned before and after fasting. Eleven rats were scanned before and after one-time CCl4 intoxication. RESULTS:For reproducibility, rat liver APTw and GlycoCEST measurements had 95 % limits

SUBMITTER: Chen SZ 

PROVIDER: S-EPMC5746030 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature