MTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation.

ABSTRACT: Antigen-presenting cells (APCs) occupy diverse anatomical tissues, but their tissue-restricted homeostasis remains poorly understood. Here, working with mouse models of inflammation, we found that mechanistic target of rapamycin (mTOR)-dependent metabolic adaptation was required at discrete locations. mTOR was dispensable for dendritic cell (DC) homeostasis in secondary lymphoid tissues but necessary to regulate cellular metabolism and accumulation of CD103⁺ DCs and alveolar macrophages in lung. Moreover, while numbers of mTOR-deficient lung CD11b⁺ DCs were not changed, they were metabolically reprogrammed to skew allergic inflammation from eosinophilic T helper cell 2 (T_H2) to neutrophilic T_H17 polarity. The mechanism for this change was indepen

SUBMITTER: Sinclair C 

PROVIDER: S-EPMC5746055 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature