Alterations in the mucosa-associated fungal microbiota in patients with ulcerative colitis.

ABSTRACT:

Background

Fungi colonize the human gut and might play a key role in the pathogenesis of ulcerative colitis (UC). However, studies on the fungal composition in the gut (especially adhering to the intestinal mucosa) of UC patients is limited.

Results

The number of fungi decreased significantly in inflamed mucosa compared with that in HS mucosa. Fifteen major genera were examined, among which Wickerhamomyces, unidentified genus of Saccharomycetales, Aspergillus, Sterigmatomyces, and Candida showed increasing trends, whereas Exophiala, Alternaria, Emericella, Epicoccum, Acremonium, Trametes, and Penicillium showed decreasing trends in UC patients compared to the HS. The pro-inflammatory cytokine

SUBMITTER: Qiu X 

PROVIDER: S-EPMC5746090 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature