Ontology highlight
ABSTRACT:
SUBMITTER: Kim TJ
PROVIDER: S-EPMC5746096 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Kim Tae-Jung TJ Hong Soon Auck SA Kim Okran O Kim Seung Joon SJ Yang Ji-Hyun JH Joung Eun Kyo EK Kang Jin-Hyoung JH Hong Sook-Hee SH
Oncotarget 20171121 64
<h4>Backgrounds</h4>EGFR-mutant non-small cell lung cancer (NSCLC) that developed acquired resistance to EGFR-tyrosine kinase (TKI) are potential candidates for programmed death 1 (PD1) inhibitor.<h4>Results</h4>TPS≥1% for PD-L1 and low CD8 <b><sup>+</sup></b> TIL in post-TKI tumor showed a trend for a lower PFS of EGFR-TKIs (14.2 <i>vs</i> 9.9 months; <i>P</i> = 0.060) (cohort A). Only 2 of 22 specimens (9.1%) with an acquired EGFR exon 20 T790M mutation exhibited in post-TKI TPS≥50% for PD-L1. ...[more]