The association of MPO gene promoter polymorphisms with Alzheimer's disease risk in Chinese Han population.

ABSTRACT:

Aim

The objective of this study was to explore the genetic association of myeloperoxidase (MPO) gene polymorphisms with risk of Alzheimer's disease (AD).

Methods

Blood samples were collected from 116 AD patients and 134 age and gender matched healthy individuals. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was utilized to confirm MPO polymorphisms in promoter region. Plasma concentration of MPO was detected by enzyme-linked immuno sorbent assay. Genotype distributions of MPO polymorphisms were compared by χ² test between the two groups. The status of linkage disequilibrium between MPO two polymorphisms was detected using Haploview. MPO concentrations were analyzed by non-parametric test.

Results

SUBMITTER: Ji W 

PROVIDER: S-EPMC5746110 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature