Clinical impact of miR-223 expression in pediatric T-Cell lymphoblastic lymphoma.

ABSTRACT: Although probability of event-free survival in pediatric lymphoblastic T-cell lymphoma (T-LBL) is about 75%, survival in relapsed patients is very poor, so the identification of new molecular markers is crucial for treatment optimization. Here, we demonstrated that the over-expression of miR-223 promotes tumor T-LBL cell growth, migration and invasion in vitro. We found out that SIK1, an anti-metastatic protein, is a direct target of miR-223 and consequently is significantly reduced in miR-223-overexpressing tumor cells. We measured miR-223 expression levels at diagnosis in tumor biopsies from 67 T-LBL pediatric patients for whom complete clinical and follow up data were available, and we found that high miR-223 expression (above the median value)

SUBMITTER: Pomari E 

PROVIDER: S-EPMC5746112 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature