LCZ696, a promising novel agent in treating hypertension (a meta-analysis of randomized controlled trials).

ABSTRACT:

Background

To determine the effectiveness and safety of LCZ696 for the clinical treatment of hypertension, we performed a meta-analysis of the previous clinical trials.

Methods

Relevant English articles and randomized controlled trials were searched in Pubmed, Embase, EBSCO, Cochrane base and ClinicalTrials.gov. The last search date was July 20th, 2017.

Results

Compared with 20mg olmesartan, 200mg and 400mg LCZ696 outperformed olmesartan in terms of reducing mean sitting systolic blood pressure, mean ambulatory systolic blood pressure, mean sitting diastolic blood pressure and mean ambulatory diastolic blood pressure. Compared with 20mg olmesartan, 200mg and 400mg LCZ696 was better than olmesartan in terms of reducing mean sitting pulse pressure. And these studies sho

SUBMITTER: Ye L 

PROVIDER: S-EPMC5746120 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature