The implication from RAS/RAF/ERK signaling pathway increased activation in epirubicin treated triple negative breast cancer.

ABSTRACT:

Background

Triple negative breast cancer (TNBC) is not sensitive to RAS/RAF/ERK signaling pathway (ERK pathway) targeting therapy, due to the absence of excessive activation of ERK pathway. However, the kinase cascades might be activated after chemotherapy in TNBC. Here we aimed to predict whether ERK pathway targeting therapy could be used as an adjuvant therapy in TNBC.

Methods

Within online GEO datasets (GSE43816 and GSE54326), gene set enrichment analysis (GSEA) was performed to detect molecular changes in epirubicin treated TNBC samples and cells, ERK pathway components and regulation genes changes were included.

Results

In epirubicin treated TNBC samples and cells, we found ERK pathway components (eg. MAPK13, MAP3K1, MAPK12, MAPK11 and MAPKAPK3) were obviously e

SUBMITTER: Huang J 

PROVIDER: S-EPMC5746140 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature