Lung Injury Repair by Transplantation of Adult Lung Cells Following Preconditioning of Recipient Mice.

ABSTRACT: Repair of injured lungs represents a longstanding therapeutic challenge. We recently demonstrated that human and mouse embryonic lung tissue from the canalicular stage of development are enriched with lung progenitors, and that a single cell suspension of canalicular lungs can be used for transplantation, provided that lung progenitor niches in the recipient mice are vacated by strategies similar to those used in bone marrow transplantation. Considering the ethical limitations associated with the use of fetal cells, we investigated here whether adult lungs could offer an alternative source of lung progenitors for transplantation. We show that intravenous infusion of a single cell suspension of adult mouse lungs from GFP+ donors, following conditioning of recipient mice with naphthalene and

SUBMITTER: Milman Krentsis I 

PROVIDER: S-EPMC5746155 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature