Oestrogen receptor negative early operable primary breast cancer in older women-Biological characteristics and long-term clinical outcome.

ABSTRACT:

Background

Older women are at the greatest risk of breast cancer development and a considerable number present with comorbidities. Although the majority of breast cancers in this age group express oestrogen receptor (ER), which makes endocrine therapy (primary or adjuvant) feasible, given the huge size of the elderly population, there remains a significant number of patients, in absolute term, whose tumours do not express ER and their management is challenging.

Methods

Of a consecutive series of 1,758 older (≥70 years) women with early operable primary breast cancer managed in a dedicated service from 1973-2010, 252(14.3%) had ER-negative (histochemical (H) score ≤50) tumours. Their clinical outcome was retrospectively reviewed and tumour samples collected from diagnostic co

SUBMITTER: Syed BM 

PROVIDER: S-EPMC5746234 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature