Novel linear motif filtering protocol reveals the role of the LC8 dynein light chain in the Hippo pathway.

ABSTRACT: Protein-protein interactions (PPIs) formed between short linear motifs and globular domains play important roles in many regulatory and signaling processes but are highly underrepresented in current protein-protein interaction databases. These types of interactions are usually characterized by a specific binding motif that captures the key amino acids shared among the interaction partners. However, the computational proteome-level identification of interaction partners based on the known motif is hindered by the huge number of randomly occurring matches from which biologically relevant motif hits need to be extracted. In this work, we established a novel bioinformatic filtering protocol to efficiently explore interaction network of a hub protein. We introduced a novel measure that enabled

SUBMITTER: Erdos G 

PROVIDER: S-EPMC5746249 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature