Targeting chaperonin containing TCP1 (CCT) as a molecular therapeutic for small cell lung cancer.

ABSTRACT: Identifying new druggable targets is desired to meet the needs for effective cancer treatments. To this end, we previously reported the efficacy of a therapeutic peptide called CT20p that displays selective cytotoxicity through inhibition of a multi-subunit, protein-folding complex called Chaperonin-Containing TCP-1 (CCT). To investigate the role of CCT in cancer progression, we examined protein levels of CCT subunits in liver, prostate, and lung cancer using human tissue microarrays. We found that these cancers expressed higher levels of CCT2 as compared to normal tissues. Small cell lung cancer (SCLC) stood out as having statistically significant difference in CCT2. Higher levels of CCT2 in tumors from lung cancer patients were also associated with decreased survival. Using SCLC cell lin

SUBMITTER: Carr AC 

PROVIDER: S-EPMC5746381 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature