Detection of prognostic methylation markers by methylC-capture sequencing in acute myeloid leukemia.

ABSTRACT: Clinical and genetic features incompletely predict outcome in acute myeloid leukemia (AML). The value of clinical methylation assays for prognostic markers has not been extensively explored. We assess the prognostic implications of methylC-capture sequencing (MCC-Seq) in patients with de novo AML by integrating DNA methylation and genetic risk stratification. MCC-Seq assessed DNA methylation level in 44 samples. The differentially methylated regions associated with prognostic genetic information were identified. The selected prognostic DNA methylation markers were independently validated in two sets. MCC-Seq exhibited good performance in AML patients. A panel of 12 differentially methylated genes was identified with promoter hyper-differentially methylated regions associated with the outco

SUBMITTER: Li Y 

PROVIDER: S-EPMC5746395 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature