Elevated Plasma Factor IXa Activity in Premenopausal Women on Hormonal Contraception.

ABSTRACT:

Objective

Combined oral contraceptives induce a reversible hypercoagulable state with an enhanced risk of venous thromboembolism, but the underlying mechanism(s) remain unclear. Subjects on combined oral contraceptives also demonstrate a characteristic resistance to APC (activated protein C) in the thrombin generation assay. Here, we report the potential role of plasma factor IXa (FIXa) as a mechanism for hormone-induced systemic hypercoagulability.

Approach and results

A novel assay was used to determine FIXa activity in plasma samples from volunteer blood donors. Plasma from 36 premenopausal females on hormonal contraception and 35 not on hormonal contraception, 35 postmenopausal females, and 10 males were analyzed for FIXa activity, total PS (protein S), total tissue fact

SUBMITTER: Tanratana P 

PROVIDER: S-EPMC5746428 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature