Inhalation of Fine Particulate Matter Impairs Endothelial Progenitor Cell Function Via Pulmonary Oxidative Stress.

ABSTRACT:

Objective

Exposure to fine particulate matter (PM_2.5) air pollution is associated with the depletion of circulating endothelial progenitor cells (EPCs), as well as vascular injury and dysfunction. Nevertheless, it remains unclear whether PM_2.5 exposure leads to significant impairments in EPC function. Hence, we studied the effects of PM_2.5 on EPC-mediated recovery of vascular perfusion after hindlimb ischemia and examined the mechanisms whereby PM_2.5 exposure affects EPC abundance and function.

Approach and results

In comparison with EPCs isolated from mice breathing filtered air, EPCs from mice exposed for 9 consecutive days (6 hours per day) to concentrated ambient PM_2.5 (CAP) had defects in both proliferation and tube

SUBMITTER: Haberzettl P 

PROVIDER: S-EPMC5746456 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature