Pursuing meaningful end-points for stem cell therapy assessment in ischemic cardiac disease.

ABSTRACT: Despite optimal interventional and medical therapy, ischemic heart disease is still an important cause of morbidity and mortality worldwide. Although not included in standard of care rehabilitation, stem cell therapy (SCT) could be a solution for prompting cardiac regeneration. Multiple studies have been published from the beginning of SCT until now, but overall no unanimous conclusion could be drawn in part due to the lack of appropriate end-points. In order to appreciate the impact of SCT, multiple markers from different categories should be considered: Structural, biological, functional, physiological, but also major adverse cardiac events or quality of life. Imaging end-points are among the most used - especially left ventricle ejection fraction (LVEF) measured through different method

SUBMITTER: Dorobantu M 

PROVIDER: S-EPMC5746641 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature