Modelling of Hydrophilic Interaction Liquid Chromatography Stationary Phases Using Chemometric Approaches.

ABSTRACT: Metabolomics is a powerful and widely used approach that aims to screen endogenous small molecules (metabolites) of different families present in biological samples. The large variety of compounds to be determined and their wide diversity of physical and chemical properties have promoted the development of different types of hydrophilic interaction liquid chromatography (HILIC) stationary phases. However, the selection of the most suitable HILIC stationary phase is not straightforward. In this work, four different HILIC stationary phases have been compared to evaluate their potential application for the analysis of a complex mixture of metabolites, a situation similar to that found in non-targeted metabolomics studies. The obtained chromatographic data were analyzed by different chemometri

SUBMITTER: Navarro-Reig M 

PROVIDER: S-EPMC5746734 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature