Ontology highlight
ABSTRACT:
SUBMITTER: Krakau S
PROVIDER: S-EPMC5746957 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Genome biology 20171228 1
The iCLIP and eCLIP techniques facilitate the detection of protein-RNA interaction sites at high resolution, based on diagnostic events at crosslink sites. However, previous methods do not explicitly model the specifics of iCLIP and eCLIP truncation patterns and possible biases. We developed PureCLIP ( https://github.com/skrakau/PureCLIP ), a hidden Markov model based approach, which simultaneously performs peak-calling and individual crosslink site detection. It explicitly incorporates a non-sp ...[more]