The effect of low intensity shockwave treatment (Li-SWT) on human myoblasts and mouse skeletal muscle.

ABSTRACT:

Background

Transplanting myogenic cells and scaffolds for tissue engineering in skeletal muscle have shown inconsistent results. One of the limiting factors is neovascularization at the recipient site. Low intensity shockwave therapy (Li-SWT) has been linked to increased tissue regeneration and vascularization, both integral to survival and integration of transplanted cells. This study was conducted to demonstrate the response of myoblasts and skeletal muscle to Li-SWT.

Method

Primary isolated human myoblasts and explants were treated with low intensity shockwaves and subsequently cell viability, proliferation and differentiation were tested. Cardiotoxin induced injury was created in tibialis anterior muscles of 28 mice, and two days later, the lesions were treated with 500

SUBMITTER: Hansen LK 

PROVIDER: S-EPMC5747105 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature