Multiple functions of CREB-binding protein during postembryonic development: identification of target genes.

ABSTRACT:

Background

Juvenile hormones (JH) and ecdysteroids control postembryonic development in insects. They serve as valuable targets for pest management. Hence, understanding the molecular mechanisms of their action is of crucial importance. CREB-binding protein (CBP) is a universal transcriptional co-regulator. It controls the expression of several genes including those from hormone signaling pathways through co-activation of many transcription factors. However, the role of CBP during postembryonic development in insects is not well understood. Therefore, we have studied the role of CBP in postembryonic development in Tribolium, a model coleopteran insect.

Results

CBP is ubiquitously expressed in the red flour beetle, Tribolium castaneum. RNA interference (RNAi) mediated knockdo

SUBMITTER: Roy A 

PROVIDER: S-EPMC5747157 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature