Use of transcriptomic data for extending a model of the AppA/PpsR system in Rhodobacter sphaeroides.

ABSTRACT:

Background

Photosynthetic (PS) gene expression in Rhodobacter sphaeroides is regulated in response to changes in light and redox conditions mainly by PrrB/A, FnrL and AppA/PpsR systems. The PrrB/A and FnrL systems activate the expression of them under anaerobic conditions while the AppA/PpsR system represses them under aerobic conditions. Recently, two mathematical models have been developed for the AppA/PpsR system and demonstrated how the interaction between AppA and PpsR could lead to a phenotype in which PS genes are repressed under semi-aerobic conditions. These models have also predicted that the transition from aerobic to anaerobic growth mode could occur via a bistable regime. However, they lack experimentally quantifiable inputs and outputs. Here, we extend one of them to

SUBMITTER: Pandey R 

PROVIDER: S-EPMC5747161 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature