Cortical thickness alterations linked to somatoform and psychological dissociation in functional neurological disorders.

ABSTRACT:

Background

Links between dissociation and functional neurological disorder (FND)/conversion disorder are well-established, yet the pathophysiology of dissociation remains poorly understood. This MRI study investigated structural alterations associated with somatoform and psychological dissociation in FND. We hypothesized that multimodal, paralimbic cingulo-insular regions would relate to the severity of somatoform dissociation in patients with FND.

Methods

FreeSurfer cortical thickness and subcortical volumetric analyses were performed in 26 patients with motor FND and 27 matched healthy controls. Patients with high dissociation as measured by the Somatoform Dissociation Questionnaire-20 (SDQ) or Dissociative Experiences Scale (DES) were compared to controls in stratified an

SUBMITTER: Perez DL 

PROVIDER: S-EPMC5747307 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature