Ontology highlight
ABSTRACT:
SUBMITTER: Blattmann P
PROVIDER: S-EPMC5747350 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Blattmann Peter P Henriques David D Zimmermann Michael M Frommelt Fabian F Sauer Uwe U Saez-Rodriguez Julio J Aebersold Ruedi R
Cell systems 20171206 6
In individuals, heterogeneous drug-response phenotypes result from a complex interplay of dose, drug specificity, genetic background, and environmental factors, thus challenging our understanding of the underlying processes and optimal use of drugs in the clinical setting. Here, we use mass-spectrometry-based quantification of molecular response phenotypes and logic modeling to explain drug-response differences in a panel of cell lines. We apply this approach to cellular cholesterol regulation, ...[more]