Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus.

ABSTRACT: Due to an aging population, the incidence of dementia is steadily rising. The ability to identify early markers in blood, which appear before the onset of clinical symptoms is of considerable interest to allow early intervention, particularly in "high risk" groups such as those with type 2 diabetes. Here, we present a longitudinal study of genome-wide DNA methylation in whole blood from 18 elderly individuals with type 2 diabetes who developed presymptomatic dementia within an 18-month period following baseline assessment and 18 age-, sex-, and education-matched controls who maintained normal cognitive function. We identified a significant overlap in methylomic differences between groups at baseline and follow-up, with 8 CpG sites being consistently differentially methylated above our nomi

SUBMITTER: Lunnon K 

PROVIDER: S-EPMC5747361 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature