Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery.

ABSTRACT:

Background

There is a clear need for better biomarkers of drug-induced-liver-injury (DILI).

Aims

We aimed to evaluate the possible prognostic value of ActiTest and FibroTest proteins apoliprotein-A1, haptoglobin and alpha-2-macroglobulin, in patients with DILI.

Methods

We analyzed cases and controls included in the IMI-SAFE-T-DILI European project, from which serum samples had been stored in a dedicated biobank. The analyses of ActiTest and FibroTest had been prospectively scheduled. The primary objective was to analyze the performance (AUROC) of ActiTest components as predictors of recovery outcome defined as an ALT <2x the upper limit of normal (ULN), and BILI <2x ULN.

Results

After adjudication, 154 patients were considered to have DILI and 22 were considere

SUBMITTER: Peta V 

PROVIDER: S-EPMC5747433 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature