Transition probabilities between changing sensitization levels, waitlist activity status and competing-risk kidney transplant outcomes using multi-state modeling.

ABSTRACT:

Background

Sensitization and activity status are associated with kidney transplant waitlist mortality. Unknown is how changes in these covariates after listing impact transplant outcomes.

Methods

Two cohorts were created from the OPTN (Organ Procurement and Transplantation Network) database, one pre-KAS (new kidney allocation system) (10/01/2009-12/04/2013, n = 97,793) and one post-KAS (12/04/2014-06/17/2015, n = 13,113). Multi-state modeling provides transition probabilities between intermediate states (CPRA category/activity status combinations) and competing-risk outcomes: transplant (living), transplant (deceased), death, or other/well.

Results

Transition probabilities show chances of converting between intermediate states prior to a competing-risk outcome. One ye

SUBMITTER: Kulkarni S 

PROVIDER: S-EPMC5747475 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature