Ethnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: A meta-analysis.

ABSTRACT:

Background

Several studies have investigated the association of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with peripheral vascular disease (PVD); however, the results remain controversial. Therefore, we conducted the current meta-analysis to evaluate this relationship in the general population of different ethnicities.

Methods

We searched PubMed, Embase, Web of Science, Wanfang Database, and CNKI to identify eligible studies. Random-effect models were applied to estimate the pooled odds ratio (OR) with a 95% confidence interval (CI), regardless of between-study heterogeneity.

Results

A total of 13 studies with 1966 cases and 6129 controls were included in this meta-analysis. The pooled ORs for the associ

SUBMITTER: Han C 

PROVIDER: S-EPMC5747497 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature