Microbial Rhodopsins: Diversity, Mechanisms, and Optogenetic Applications.

ABSTRACT: Microbial rhodopsins are a family of photoactive retinylidene proteins widespread throughout the microbial world. They are notable for their diversity of function, using variations of a shared seven-transmembrane helix design and similar photochemical reactions to carry out distinctly different light-driven energy and sensory transduction processes. Their study has contributed to our understanding of how evolution modifies protein scaffolds to create new protein chemistry, and their use as tools to control membrane potential with light is fundamental to optogenetics for research and clinical applications. We review the currently known functions and present more in-depth assessment of three functionally and structurally distinct types discovered over the past two years: (a) anion channelrho

SUBMITTER: Govorunova EG 

PROVIDER: S-EPMC5747503 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature