The Spatial Relationship between Apparent Diffusion Coefficient and Standardized Uptake Value of ¹⁸F-Fluorodeoxyglucose Has a Crucial Influence on the Numeric Correlation of Both Parameters in PET/MRI of Lung Tumors.

ABSTRACT: The minimum apparent diffusion coefficient (ADC_min) derived from diffusion-weighted MRI (DW-MRI) and the maximum standardized uptake value (SUV_max) of FDG-PET are markers of aggressiveness in lung cancer. The numeric correlation of the two parameters has been extensively studied, but their spatial interplay is not well understood. After FDG-PET and DW-MRI coregistration, values and location of ADC_min- and SUV_max-voxels were analyzed. The upper limit of the 95% confidence interval for registration accuracy of sequential PET/MRI was 12 mm, and the mean distance (D) between ADC_min- and SUV_max-voxels was 14.0 mm (average of two readers). Spatial mismatch (D > 12 mm) between ADC_min and SUV_max w

SUBMITTER: Sauter AW 

PROVIDER: S-EPMC5748125 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature