Cytotoxic halogenated monoterpenes from Plocamium cartilagineum.

ABSTRACT: As a result of our efforts to identify bioactive agents from marine algae, we have isolated and identified one new halogenated monoterpene 1 [(-)-(5E,7Z)-348-trichloro-7-dichloromethyl-3-methyl-157-octatriene] in addition to three known compounds (2, 3 and 4) from the red alga Plocamium cartilagineum collected by hand from the eastern coast of South Africa. Compound 1 was found to be active as a cytotoxic agent in human lung cancer (NCI-H460) and mouse neuro-2a cell lines (IC₅₀ 4 μg/mL). Two of these compounds (3 and 4) were found to have cytotoxic activity in other cell line assays, especially against human leukaemia and human colon cancers (IC₅₀ 1.3 μg/mL). None of these metabolites were active as sodium channel blockers or activators. All structures were determined

SUBMITTER: Sabry OM 

PROVIDER: S-EPMC5748142 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature