Effects of mutation and selection on plasticity of a promoter activity in Saccharomyces cerevisiae.

ABSTRACT: Phenotypic plasticity is an evolvable property of biological systems that can arise from environment-specific regulation of gene expression. To better understand the evolutionary and molecular mechanisms that give rise to plasticity in gene expression, we quantified the effects of 235 single-nucleotide mutations in the Saccharomyces cerevisiae TDH3 promoter (P_TDH3 ) on the activity of this promoter in media containing glucose, galactose, or glycerol as a carbon source. We found that the distributions of mutational effects differed among environments because many mutations altered the plastic response exhibited by the wild-type allele. Comparing the effects of these mutations with the effects of 30 P_TDH3 polymorphisms on expression pl

SUBMITTER: Duveau F 

PROVIDER: S-EPMC5748197 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature