Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney.

ABSTRACT: During kidney development, progressively committed progenitor cells give rise to the distinct segments of the nephron, the functional unit of the kidney. Similar segment-committed progenitor cells are thought to be involved in the homeostasis of adult kidney. However, markers for most segment-committed progenitor cells remain to be identified. Here, we evaluate Troy/TNFRSF19 as a segment-committed nephron progenitor cell marker. Troy is expressed in the ureteric bud during embryonic development. During postnatal nephrogenesis, Troy⁺ cells are present in the cortex and papilla and display an immature tubular phenotype. Tracing of Troy⁺ cells during nephrogenesis demonstrates that Troy⁺ cells clonally give rise to tubular structures that persist for up

SUBMITTER: Schutgens F 

PROVIDER: S-EPMC5748200 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature