Cytoplasmic Cl^- couples membrane remodeling to epithelial morphogenesis.

ABSTRACT: Chloride is the major free anion in the extracellular space (>100 mM) and within the cytoplasm in eukaryotes (10 ∼ 20 mM). Cytoplasmic Cl^- level is dynamically regulated by Cl^- channels and transporters. It is well established that movement of Cl^- across the cell membrane is coupled with cell excitability through changes in membrane potential and with water secretion. However, whether cytoplasmic Cl^- plays additional roles in animal development and tissue homeostasis is unknown. Here we use genetics, cell biological and pharmacological tools to demonstrate that TMEM16A, an evolutionarily conserved calcium-activated chloride channel (CaCC), regulates cytoplasmic Cl^- homeostasis and promotes plasma membrane remodeling required for mammal

SUBMITTER: He M 

PROVIDER: S-EPMC5748203 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature