Odor cueing during slow-wave sleep benefits memory independently of low cholinergic tone.

ABSTRACT:

Rationale

Sleep-dependent memory consolidation depends on the concerted reactivation of memories in the hippocampo-neocortical system. The communication of reactivated information from the hippocampus to the neocortex is assumed to be enabled by low levels of acetylcholine, particularly during slow-wave sleep (SWS). Recent studies suggest that the reactivation of memories does not only occur spontaneously but can also be externally triggered by re-presenting learning-associated cues during sleep.

Objectives

Here we investigated whether the beneficial effect of cued memory reactivation during sleep depends on similar mechanisms as spontaneous reactivation, and specifically on low cholinergic tone.

Methods

In two experimental nights, healthy volunteers learned a visuo-s

SUBMITTER: Klinzing JG 

PROVIDER: S-EPMC5748395 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature