The 5-HT_2C receptor agonist meta-chlorophenylpiperazine (mCPP) reduces palatable food consumption and BOLD fMRI responses to food images in healthy female volunteers.

ABSTRACT:

Rationale

Brain 5-HT_2C receptors form part of a neural network that controls eating behaviour. 5-HT_2C receptor agonists decrease food intake by activating proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus, but recent research in rodents has suggested that 5-HT_2C receptor agonists may also act via dopaminergic circuitry to reduce the rewarding value of food and other reinforcers. No mechanistic studies on the effects of 5-HT_2C agonists on food intake in humans have been conducted to date.

Objectives

The present study examined the effects of the 5-HT_2C receptor agonist meta-chlorophenylpiperazine (mCPP) on food consumption, eating microstructure and blood oxygen level-dependent (BOLD) functional

SUBMITTER: Thomas JM 

PROVIDER: S-EPMC5748416 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature