Shared cancer neoantigens: Making private matters public.

ABSTRACT: In this issue of JEM, Chheda et al. (https://doi.org/10.1084/jem.20171046) report that a conserved hotspot mutation associated with an aggressive form of brain cancer generates an immunogenic T cell epitope restricted by a common HLA subtype, thereby creating a "public" neoantigen.

SUBMITTER: Klebanoff CA 

PROVIDER: S-EPMC5748868 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature