Sulfonamides as Inhibitors of Leishmania - Potential New Treatments for Leishmaniasis.

ABSTRACT:

Introduction

Leishmaniasis is an endemic disease caused by the protozoan parasite Leishmania. Current treatments for the parasite are limited by cost, availability and drug resistance as the occurrence of leishmaniasis continues to be more prevalent. Sulfonamides are a class of compounds with medicinal properties which have been used to treat bacterial and parasitic disease via various pathways especially as antimetabolites for folic acid.

Methods

New derivatives of sulfonamide compounds were assessed for their impact on Leishmania cell viability and potential pathways for inhibition were evaluated. Leishmania tarentolae (ATCC Strain 30143) axenic promastigote cells were grown in brain heart infusion (BHI) medium and treated with varying concentrations of the new sulfonamide

SUBMITTER: Katinas J 

PROVIDER: S-EPMC5748876 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature