Aldosterone Is Essential for Angiotensin II-Induced Upregulation of Pendrin.

ABSTRACT: The renin-angiotensin-aldosterone system has an important role in the control of fluid homeostasis and BP during volume depletion. Dietary salt restriction elevates circulating angiotensin II (AngII) and aldosterone levels, increasing levels of the Cl^-/HCO₃^- exchanger pendrin in β-intercalated cells and the Na⁺-Cl^- cotransporter (NCC) in distal convoluted tubules. However, the independent roles of AngII and aldosterone in regulating these levels remain unclear. In C57BL/6J mice receiving a low-salt diet or AngII infusion, we evaluated the membrane protein abundance of pendrin and NCC; assessed the phosphorylation of the mineralocorticoid receptor, which selectively inhibits aldosterone binding in intercalated cells; and measured

SUBMITTER: Hirohama D 

PROVIDER: S-EPMC5748905 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature