Cardiovascular Effects of Renal Distal Tubule Deletion of the FGF Receptor 1 Gene.

ABSTRACT: The bone-derived hormone fibroblast growth factor-23 (FGF-23) activates complexes composed of FGF receptors (FGFRs), including FGFR1, and α-Klotho in the kidney distal tubule (DT), leading to increased sodium retention and hypertension. However, the role of FGFR1 in regulating renal processes linked to hypertension is unclear. Here, we investigated the effects of selective FGFR1 loss in the DT. Conditional knockout (cKO) of FGFR1 in the DT (FGFR1^DT-cKO mice) resulted in left ventricular hypertrophy (LVH) and decreased kidney expression of α-Klotho in association with enhanced BP, decreased expression of angiotensin converting enzyme 2, and increased expression of the Na⁺-K⁺-2Cl^- cotransporter. Notably, recombinant FGF-

SUBMITTER: Han X 

PROVIDER: S-EPMC5748915 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature