Endotoxin Preconditioning Reprograms S1 Tubules and Macrophages to Protect the Kidney.

ABSTRACT: Preconditioning with a low dose of endotoxin confers unparalleled protection against otherwise lethal models of sepsis. The mechanisms of preconditioning have been investigated extensively in isolated immune cells such as macrophages. However, the role of tissue in mediating the protective response generated by preconditioning remains unknown. Here, using the kidney as a model organ, we investigated cell type-specific responses to preconditioning. Compared with preadministration of vehicle, endotoxin preconditioning in the cecal ligation and puncture mouse model of sepsis led to significantly enhanced survival and reduced bacterial load in several organs. Furthermore, endotoxin preconditioning reduced serum levels of proinflammatory cytokines, upregulated molecular pathways involved in pha

SUBMITTER: Hato T 

PROVIDER: S-EPMC5748923 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature