Heterogeneity of PD-L1 expression in primary tumors and paired lymph node metastases of triple negative breast cancer.

ABSTRACT:

Background

Programmed cell death ligand 1 (PD-L1) is a potential predictive biomarker of the response to anti-PD-L1/anti- programmed cell death 1 (PD-1) therapy in multiple cancers, including triple negative breast cancer(TNBC). The purpose of this study was to investigate whether PD-L1 expression is homogenous in primary tumors(PTs) and synchronous axillary lymph node metastases(LNMs) of TNBC.

Methods

PD-L1 expression was immunohistochemically evaluated in 101 TNBC patients' PTs and paired LNMs. PD-L1 expression in tumor cells and infiltrating immune cells or node lymphocytes in the PTs and associated LNMs was scored separately and was correlated with patients' clinical parameters and prognoses.

Results

PD-L1 expression exhibited spatial heterogeneity in both the tum

SUBMITTER: Li M 

PROVIDER: S-EPMC5748959 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature