Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells.

ABSTRACT: Centrosome amplification is a common feature of human tumors. To survive, cancer cells cluster extra centrosomes during mitosis, avoiding the detrimental effects of multipolar divisions. However, it is unclear whether clustering requires adaptation or is inherent to all cells. Here, we show that cells have varied abilities to cluster extra centrosomes. Epithelial cells are innately inefficient at clustering even in the presence of HSET/KIFC1, which is essential but not sufficient to promote clustering. The presence of E-cadherin decreases cortical contractility during mitosis through a signaling cascade leading to multipolar divisions, and its knockout promotes clustering and survival of cells with multiple centrosomes. Cortical contractility restricts centrosome movement at a minimal dist

SUBMITTER: Rhys AD 

PROVIDER: S-EPMC5748979 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature